How to write a paper

15 Biology terms

abrogate

to suppress or prevent a biological function or process.

Example: "We also transiently upregulated IGF2BP1 in HCC cells with LINC01093 overexpression and observed that ectopic expression of IGF2BP1 could abrogate the decrease in GLI1 downstream molecules."[3]

aggravate

make (a problem, injury, or offense) worse or more serious.

Example: "These findings suggested that there was high expression in inflammatory factors in the serum of mice with AH and that the mice with AH exhibited severe lesions in the hepatic tissues, higher AI, and aggravated inflammation."[2]

alleviate

Essential Meaning of alleviate : to reduce the pain or trouble of (something) : to make (something) less painful, difficult, or severe

Example: "These findings suggest that the highly expressed SIRT1 protein in hepatocytes may alleviate liver fibrosis."[1]

attenuate

reduce the force, effect, or value of.

Example: "Similarly, overexpressed lncRNA growth arrest-specific transcript 5 could attenuate liver fibrosis by inhibiting the activation and proliferation of hepatic stellate cell."[2]

cancer embolus

Pulmonary tumor embolism occurs when solid tumors seed the systemic circulation with individual cells, clusters of cells, or large tumor fragments.

Example: "The inverse correlation between LINC01093 expression and the existence of cancer embolus in HCC patients prompted us to explore the effect of LINC01093 in cell invasion and metastasis."[3]

dampen

make less strong or intense.

Example: "It could directly interact with the glioma-associated oncogene homolog 1 (GLI1) mRNA, dampening its degradation."[3]

elucidate

make (something) clear; explain.

Example: "We aim to elucidate whether LINC01093 exerts the anti-fibrotic effect via regulating SIRT1, as well as the specific molecular mechanisms."[1]

implicate

to involve in the nature or operation of something.

Example: "LncRNA-associated biological regulation has been implicated in many cellular processes, including liver fibrosis."[1]

intrinsic apoptosis pathway

The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway.

Example: "The previous report described that caspase-3 was considered a central executor involved in the mitochondrial-dependent apoptosis pathway and Bax, which also participated in the inactivation of the intrinsic apoptosis pathway."[2]

jaundice

a medical condition with yellowing of the skin or whites of the eyes, arising from excess of the pigment bilirubin and typically caused by obstruction of the bile duct, by liver disease, or by excessive breakdown of red blood cells.

Example: "AH, like several other types of liver injury, develops as a result of chronic alcohol abuse and presents with jaundice and liver failure in patients who had severe alcohol abuse for decades."[2]

perisinusoidal space

a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes.

Example: "In contrast with the control group, the mice in the AH group were observed to have severe hepatic fibrosis, with some mice presenting with a disorderly hepatic lobule structure, and the collagen fibers were increased and extended to the perisinusoidal space with an increase of perisinusoidal fibrous tissue."[2]

promote

To contribute to the growth or prosperity of sth.

Example: "These hepatocyte-derived apoptotic bodies can directly induce the activation of HSCs, which are the main sources of ECM, thus promoting the expressions of ECM proteins like Collagen I and a-smooth muscle actin (a-SMA), and finally aggravating liver fibrosis."[1]

quiescent

: marked by inactivity or repose : tranquilly at rest

Example: "The initial discoveries in HSCs indicated that PPAR-c expression was markedly decreased when HSCs were transdifferentiated from a quiescent phenotype to an activated/fibrogenic phenotype."[1]

superenhancer

In genetics, a super-enhancer is a region of the mammalian genome comprising multiple enhancers that is collectively bound by an array of transcription factor proteins to drive transcription of genes involved in cell identity.

Example: "These findings are in line with the results in our study. Moreover, TGF-b was considered a critical activator of fibrosis, and lncRNAs regulated by TGF-b were enriched in superenhancers, suggesting that lncRNAs may exert critical effects on hepatic stellate cell function and fibrosis."[2]

truncated

shortened in duration or extent.

Example: "Therefore, we cloned full-length and truncated fragments of GLI1 into the region downstream of the firefly luciferase gene of the pGL3-Control vector."[3]